The liver is composed of liver cells, and extensive vascular network, was reddish-brown, soft and crisp, vulnerable to violence and rupture caused fatal bleeding.
Minimal liver cells, it is necessary to see through the microscope. Liver about 2.5 billion liver cells, liver cells 5000 Hepatic Lobules one, the human liver Hepatic Lobules total of around 500,000, liver cells polygon diameter of about 20 to 30 microns, 6-8 face, volume of about 4,900 square micron, under different physiological conditions of the there are small differences, such as hunger, the largest volume of liver cells.
Each cell surface can be divided into liver sinusoidal surface, the surface of liver cells and cowardice of the three. Liver cells it contains many complicated fine structure: If liver cells, liver cytoplasm, mitochondria, endoplasmic reticulum and lysosomes, Gorky's body, and drink vacuole of particulate components. Each has its fine structure is extremely important and complex functions, which ensures the existence of human life, that people can live.
Liver cells
It is the function of replication of genetic information. Hepatitis, hepatitis C virus invasive liver cells, the virus genes in the DNA of liver cells combine (integration). Once integration is difficult HBsAg clearance, which carry long HBsAg.
Mitochondria
Each liver cell mitochondria of 1000-2000, of which more than 70 certificates of enzymes and coenzyme, such as ALT (SGPT or ALT, or aminotransferase), respiratory enzyme cells, and adenosine triphosphate. When hunger, systemic hypoxia, or cholestatic hepatitis, mitochondria is the first and most sensitive of the victim, extreme swelling caused elevated liver transaminases, biochemical disorder.
Endoplasmic reticulum
The cytoplasm of the hepatocytes was flat or bubble tubular cystic structure. The rough endoplasmic reticulum and smooth endoplasmic reticulum two.
The rough endoplasmic reticulum protein synthesis of liver cells is a base, and can be a surplus of a few amino acid to another amino acid. Hepatic uptake of amino acid protein synthesis very quickly. Generally, albumin is the rough endoplasmic omentum on the synthesis of multi-synuclein. Slide endoplasmic reticulum widely distributed in the cytoplasm of liver, often with the rough endoplasmic reticulum and Golgi's body linked to the three functions are closely linked.
Slide endoplasmic reticulum is the rough endoplasmic reticulum of 2.5 to 3.2 times. The membrane has many enzymes, such as oxidoreductase of hydrolysis enzymes, synthetic enzyme, and so on. The glycogen synthesis and decomposition, fat metabolism, hormone metabolism, drug metabolism and detoxification process and the synthesis of bile are smooth endoplasmic reticulum conducted. Furthermore, the uptake of liver cells in many organic smooth endoplasmic online Synthesis, decomposition, the integration of biochemical reactions.
Hepatitis, the endoplasmic reticulum damage reduction in albumin production, protein metabolism, resulting in the patients with serum albumin and globulin ratio (A / G) inversion, flocculation test and turbidity test abnormalities. Because of fibrinogen and thrombin original manufacturer reduced, resulting in bleeding tendency. Because glycogen reduced, leading to low blood sugar. As detoxification weakened, leading to enhanced toxicity of drugs. Since bilirubin metabolism, indirectly blush of bile into direct bilirubin, the process is in the endoplasmic reticulum, the endoplasmic reticulum in liver cell damage, jaundice, resulting in the skin, sclera stained.
Lysosomes
Liver cells in lysosomes containing rich, mainly distributed in the hepatic duct near capillary cytoplasm, a single membrane surrounding the dense body, 0.4 microns in diameter, contains a variety of digestive enzymes can analyze protein, sugar, fat, such as nucleic acid and phosphoric acid. Degenerative aging can digest the endoplasmic reticulum, mitochondria, cells and others. Foreign bodies, thereby maintaining the content of liver cell self-renewal, has been hailed as the cell's "digestive system" and "cleaners." Obstructive jaundice, bile pigment lysosomal actively involved in the transfer, hepatitis, oxygen, increased cholesterol or partial hepatectomy, the lysosome increased significantly. Hepatitis viruses can cause direct damage to the lysosome and adjacent normal liver cells and dissolved necrosis.
Gorky's body
Each liver cells about 50 Gorky's body found in the vicinity of liver cells, accounting for 10% of the volume of the cytoplasm. Gorky's body and liver cells and exocrine and endocrine functions are closely related, such as bile secretion on its closely related. While participation of the cytoplasmic membrane glycoprotein and the initial formation of lysosomes. Liver cell protein and lipoprotein synthesis, part of the body transferred to Gorky's storage processing, sinus further into the perirenal space.
Microsomal
Particulate body is the main enzyme catalase and peroxidase. To prevent hydrogen peroxide accumulation in the cell. Microsomal can be reduced coenzyme oxidation. Also in the microsomal metabolism of alcohol and gluconeogenesis and the enzymes. And also on cholesterol metabolism. Hepatocellular carcinoma cells of the particulate reduction.
Drink vacuole
With absorption and intracellular transport of material function.