Liver reticuloendothelial system constitutes an important component of the immune is the vital organs, and actively participate in the normal immunization activities, it does not directly produce antibodies, but a large number of macrophages, the immune play an important role.
     The liver macrophages is fixed, said Kupffer cells from the intestine to the antigen particles, mostly in the liver phagocytic Kupffer cells and removal. General and macrophages different Kupffer cells with increased immunogenicity of the antigen, contrary to eliminate or reduce the role of antigen. Kupffer cells can macrophages from the blood circulating antigen-antibody complexes and other harmful substances, to eliminate these substances in the body damage.
     Litter is sinusoidal's cell in the phagocytic cells to circulating immune complexes right to effective treatment, liver sinusoids is to remove serum circulating immune complexes of the largest venues. Liver can complement a variety of synthetic ingredients, liver function attenuation, complement content decreased significantly, so the liver function of the immune regulation play an important role.